DARU Journal of Pharmaceutical Sciences 2007. 15(2):89-93.

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES
Foroumadi A., Sheibani V., Sakhteman A., Rameshk M, Abbasi M., Farazifard R., Tabatabai S.A., Shafiee A

Abstract


Several novel 2-amino-5-[4-chloro-2-(2-chlorophenoxy)phenyl]-1,3,4-thiadiazole derivatives 4a-d were synthesized and their anticonvulsant activity was determined by evaluation of the ability of theses compounds to protect mice against convulsion induced by a lethal doses of pentylentetrazole (PTZ) and maximal electroshock (MES).
The result of anticonvulsant data shows that among the synthesized compounds, 5-[4-chloro-2-(2-chlorophenoxy)phenyl]-N-ethyl-1,3,4-thiadiazol-2-amine 4c was the most active compound in both MES and PTZ tests with an ED50 of 20.11 and 35.33 mg/kg, respectively.

Keywords


1,3,4-thiadiazole, Anticonvulsant activity, Maximal electroshock,

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