DARU Journal of Pharmaceutical Sciences 2010. 0(1):1-5.

Relationship between serum Vitamin D concentration and Metabolic Syndrome among Iranian Adults Population
A Hossein-Nezhad, Nikoo Khoshniat, M Maghbooli, Z Karimi, F Mirzaei, A Hosseini, B Larijani


Background and the purpose of the study:There are increasing evidences about relationship between vitamin D metabolism and occurrence of diabetes mellitus. Vitamin D has a role in secretion and possibly the action of insulin and modulates lipolysis and might therefore contribute to the development of the metabolism. The aim of this study was to investigate the nature and strength of the association between vitamin D concentration and the metabolic syndrome (MS) in Iranian population.

Methods: A cross-sectional study was conducted on 646 healthy population who had no history of diabetes. The MS was defined according to WHO criteria. The concentrations of vitamin D, and parathyroid hormone (PTH) were also measured.

Results and major conclusion: Of the total 646 participants, the unadjusted prevalence of the MS was 18.3% (29% in men and 14.6% in women). The total prevalence of vitamin D deficiency was 72.3%. Amongst the men with vitamin D deficiency the prevalence of the MS was higher than those with normal vitamin D (p=0.03). In the logistic regression model, after age and sex adjustment, vitamin D deficiency predicted independently the metabolic syndrome (p=0.001).Vitamin D deficiency and the MS have a high prevalence among Iranian adult population. The finding of this investigation revealed that vitamin D deficiency may have an important role in metabolic syndrome and its components.


metabolic syndrome,, Vitamin D, Insulin resistance,

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