EFFECT OF ORAL INSULIN IN BLOOP G1UCOSE CONCENTRATION

Abstract

Gastrointestinal tract can not be used as a route for oral administration of polypeptid hormones because
of their enzymatic degradation.
Degradation of these macromoleculcs in acidic and alkaline conditions determines the need for using
protective delivery systems.
In this research microcmulsions were used for protection of insulin against proteolytic enzymesof
gastrointestinal tract. Cholestrol and phospholipids of egg yolk have been used as lipid phase as lipid phase
and Lecithin as surfactant.
Insulin Regular was used as aqueous phase, being entrapped with lipidic phase in W/O manner. Male
rabbits with body weight of about 1-1.5 KG were accomplished and oral insulin was force fed to them.
Blood collection has been carried out from heart every 15 minutes after oral administration.
Reduction in blood glucose level indicates the well being protection of insulin and absorbtion of it through
epithelium of small intestine. Increasing of glucose level in placebo demonstrates that endogenous
insulin has not been responsible for serum glucose reduction.
This experiment suggests that microemulsions formed with egg Yolk compounds have the ability to be an
alternate for parenteral administration of insulin and other chemicals sensitive to enzymatic degradation, in
human.