DARU Journal of Pharmaceutical Sciences 2001. 9(1-2):41-43.

The effects of Piperine on the jumping induced by Naloxone in Morphine dependent mice
Moghadam Nia AA, Afraz E


Black pepper has been used in traditional medicine as an analgesic. In this investigation, the effects of piperine, an alkaloid derived from black pepper seeds on the jumping induced by naloxone were studied on morphine dependent mice. This experimental study was conducted on case (piperine) and control (saline) groups of mice. Mice were made dependent to morphine using Marshall method. For evaluation of dependency, the number of jumps after naloxone injection was counted in a period of 30 minutes. There was a significant difference between number of jumps of mice in saline (10 ml/kg, IP) and drug groups (piperine 25, 50, 75 mg/kg, IP), as well as significant differences in latency period for jumping behavior in two groups. Based on these results, piperine may affect the intensity of morphine dependency.


Black pepper, Piperine, Morphine dependency, Analgesia,

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