"Sustained release formulation of Metoclopramide Hydrochloride "

Abstract

In this research, several formulations containing, an anti emetic agent (Metoclopramide hydrochloride), a hydrophilic polymer (hydroxypropylmethylcellulose) and a hydrophobic polymer (ethylcellulose 10 cP) were prepared by direct compression. Different factors such as: the effect of different ratios of the polymers, particle size, pressure force and differences of release in acidic and distilled water as media were investigated. After developing the ideal formulation, the effect of changing the ratio of drug in core: coating on the formulation was investigated. Coating of tablets with ethylcellulose, changed the release mechanism of drug and shifted it to near zero order release. The results showed that except when matrices were coated with ethylcellulose, drug release was proportioned to the square root of time, which might be due to the change of release pattern from matrix to reservoir system.