DARU Journal of Pharmaceutical Sciences 2000. 8(3-4):1-7.

"Phase diagrams of Lecithin-based microemulsions containing Sodium Salicylate "
"Aboofazeli R, Mortazavi SAR, Khoshnevis P "


Partial phase diagrams were constructed at 25°C to investigate the phase behaviour of systems composed of soybean lecithin, water, sodium salicylate, alcohol and isopropyl myristate. The lecithins used were the commercially available soy bean lecithins, namely E200 and E170 (phosphatidyl choline purities greater than 95% and 68-72% respectively). The cosurfactants employed were n-propanol, 2-propanol and n-butanol and these were used at lecithin/alcohol weight ratios (Km) of 1:1 and 1.5:1. At a given Km, the aqueous phase consisted of a 2% w/w sodium salicylate solution. Phase diagrams showed the area of existence of a stable isotropic region along the surfactant/oil axis (i.e., reverse microemulsion area). The extension of the microemulsion domain was influenced by the purity of surfactant, the lecithin/alcohol weight ratios and the kind of the alcohol.


Microemulsion, Co-surfactant, Partial phase diagram, Soybean lecithin, Sodium salicylate, Phase behavior,

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