Study of Afecting agents on physical Properties of Aspirin- Tableted Microcapsules

Abstract

IR disc preparation device at different compression forces.lt was shown t constant compression force, the particle size of microcapsules has no influence on tablet thickness but the tablet hardness was in direct relation with particle size. The tablets prepared with microcapsules and P.V.P. were thicker than those
obtained from microcapsules on its own and mixture of microcapsules and lactose. The hardness of tablets
2 prepared with microcapsules alone remained unchanged at compression forces superior to 100 kg / cm .
Whereas the hardness of tablets containing mixture of lactose and microcapsules increased as the compression force went up. Finally, the hardness of tablets obtained from P.V.P and microcapsules decrease at high compression forces.
These considerations nature of excipient and compression force modify considerably the hardness, thickness and porosity of tablets.