DARU Journal of Pharmaceutical Sciences 2005. 13(3):100-104.

"Chemical composition and antimicrobial activity of the essential oil of Ferulago Bernardii Tomk. and M. Pimen"
"Farahnaz Khalighi-Sigaroodi, Abbas Hadjiakhoondi, Ahmad Reza Shahverdi, Vali-Allah Mozaffarian, Abbas Shafiee"


The chemical composition of the essential oil of the aerial parts of Ferulago Bernardii from Iran was analysed by GC and GC/MS. Sixty constituents were found representing 87.9% of the oil. The main constituents of the essential oil were 2,4,5-trimethyl-benzaldehyde (21.2%), α-pinene (17.0%),spathulenol (5.0%), cis-chrysanthenyl acetate (4.4%) and caryophyllene oxide (3.2%). Antimicrobial activity of the essential oil of Ferulago Bernardii by the broth dilution method in comparison with Gentamycin and Fluconazole as standard showed weak activity against Staphylococcus aureus, Bacilus subtilis, Escherichia coli, Candida albicans and Aspergillus niger. The essential oil did not show any activity against Pseudomonas aeruginosa.


"Ferulago Bernardii, 2,4,5-trimethyl-benzaldehyde, Antimicrobial activity",

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