DARU Journal of Pharmaceutical Sciences 2003. 11(2):74-78.

Syntheses and Anticonvulsant Activity of N4-Substituted Triazolylthiazoles
Maria Bineshmarvasti, Mohammad Sharifzadeh, Amir Reza Jalilian, Kambiz Soltaninejad Abbas Shafiee


Due to the good anticonvulsant activity of various 1,2,4-triazoles, several new N4-substituted triazolylthiazoles were prepared by the general method for 1,2,4-triazole ring closure. Anticonvulsant activity of compounds was measured against pentylenetetrazole-induced seizures in mice by intraperitoneal injections of different doses of the test compounds. Pretreatment of animals with flumazenil (10 mg/kg, i.p.) as a benzodiazepine receptors antagonist did not have any significant effect on anticonvulsant activity of the test compounds. These results demonstrate that the anticonvulsant activity of N4-substituted triazolylthiazole agents is not probably mediated by direct interaction with benzodiazepine receptor complex.


1,2,4-Triazoles, Anticonvulsant, Thiazoles, Flumazenil, Pentylenetetrazole,

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