DARU Journal of Pharmaceutical Sciences 2003. 11(1):23-7.

Comparartive Study of Zataria Multiflora and Anthemis Nobelis Extracts With Myrthus Communis Preparation in The Treatment of Recurrent Aphthous Stomatitis
Shahin Jafari, Massoud Amanlou, Katayoun Borhan-mojabi, Hassan Farsam


Recurrent aphthous stomatitis (RAS) is a prevalent and complicated disorder and its management is directed toward treatment of symptoms. The purpose of this study was to compare the efficacy of three herbal preparations in the management of RAS. One hundred and one out of 115 patients with minor aphthae were selected and randomly divided into four groups. Groups A, B and C received topical preparations of Zataria multiflora, Anthemis nobilis and a 50 % (v/v) mixture of Zataria multiflora and Anthemis nobilis respectively. Groups D (positive control) received Myrthus communis (Myrtle, mouth rinse), which reported to be efficient in the management of RAS. The time of pain elimination and the duration of the thorough healing were recorded. Mean time of pain elimination showed significant differences (p<0.01) between groups A (3.00±1.14 day), C (3.08±1.84 days) and D (4.30±2.12 days) with group B (5.20±3.11 days). The mean duration of healing also showed significant differences (p<0.03) between groups A (6.00±2.80 days), C (6.70±2.70 days) and D (7.60±3.10 days) with B (8.70±3.90 days). No significant differences were observed between groups A and C with group D (positive control). The result obtained for treatment with Z. multiflora (group A) was similar to that of group C, but better than M. communis (group D). Findings of this study revealed that Z. multiflora extract showed better effects than M. communis which is reported to be effective in the treatment of RAS. It is concluded that the Z. Multiflora extract is an effective product for the management of minor aphthae.


Zataria multiflora, Anthemis nobilis, Myrthus communis, Aphthous stomatitis,

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