A New Sensitive Procedure for the Determination of Codeine in Pharmaceuti Preparations

Abstract

A spectrophotometry procedure for the determination of codeine based on the reaction with bromthymol blue was developed. A yellow complex forms and is easily extractrable by chloroform at PH 5.6. The mole ratio of bromthymol blue in the complex is 1:1. The absorbance of the complex obeys Beer's law over the concentratic range of 2-14 ug of codeine per ml of chloroform. This procedure can be carried out in the presence of many common excipients without interference. In the presence of morphine to the extent of 60% of codeine present the analysis of codeine could be carried out without interference.