DARU Journal of Pharmaceutical Sciences 1990. 1(2):85-94.

A Study on the Constituents, Toxic Effects and Antihelminthic Activity of pjourotus Sryngii
H. Samsam Sheriat, T. Ghafghazi, H. Farid


Plourotus eryngii fungi which is known as mountain Fungi is grown in Bakhtiari province. The people of this region use the fresh fungi as food and its dried powder as an antihelminthic drug. Because of its use as food and drug, it was*decided to study the phytochemistry and pharmacological activities of this plant. The results are briefly as follows.
1. The presence of protein (31.37%), Fat (2,83%) , sugar (glucose and pentose), organic substances (10.47%), Gum and Mucilage (4.65%), Cl,N,P,Fe,K,Na,Mg, Ca, was proved.
2. The fungi showed to have Alkaloid, Unsaturated esterols, Flavonoides,Essence and bitter substances. Also the plant was tested for tannins, saponins, entraquinon glycosides and heart glycosides but none of these substances were present.
3. The LD of water and methanol extracts (lg/ml/kg) in mice were 5 and lOg/kg respectively.
Both plant extracts depressed the central nervous system and caused ataxia and decreased the respiration rate. It also produced diarrhea in mice. 4. Using In vitro and In vivo techniques, the anthelminthic effects of water
extract of this plant was studied. The results showed the extract can prevent the larvae production of Ascaris Lumbricoides eggs.The extract also affected the eggs of Fasciola hepatica, Dicrocoelium dendriticum and prevented opening of operculate and the release of miracidium. In case of release of miracidium, the extract had a lethal effect on it.
Finally, the extract had antihelminthic activity on mature Dicrocoelium dendriticum, this effect increases with increasing extract concentrations


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