DARU Journal of Pharmaceutical Sciences73ESSENTIAL OILS OF PYCNOCYCLA FLABELLIFOLIA (BOISS.) BOISS. AND MALABAILA SECACULE (MILLER) BOISS. FROM IRAN13M. YARIZ. AGHJANIS. MASOUDIA. MONFARED. A. RUSTAIYAN20151006The composition of the essential oils from two Umbelliferae species of Iran were analyzed by GC and GC/MS . a- Phellandrene (64.0%) and p- cymene (18.5%) were the main compo¬nents among the nintheen constituents characterized in the oil of Pycnocycia flabeUifolia representing 94.2% of the total components detected. Sixteen compounds were identified in the oil of Malabaila secacide representing 80.4% of the total oil with (3 - elemene (27.1%)and hexyl 3- methyl butanoate (15.6%) as the major constituents.https://daru.tums.ac.ir/index.php/daru/article/view/77https://daru.tums.ac.ir/index.php/daru/article/download/77/77DARU Journal of Pharmaceutical Sciences73THE POSSIBILITY OF CORRELATION BETWEEN EXTENT OF PARASITAEMIA ANDCHLOROQUINESERUMCONCENTRATION IN MALARIAL PATIENTS49H. TAJERZADEH MR. ROUINI20151006Eight male Iranian patients, aged 18-50 years and weighed 52-60 kg, suffering from acute malaria were administered 600 mg Chloroquine base (4 tablets of 150 mg). Blood samples were taken before and 1, 2, 3, 4, 5 and 6 hours after dosing . Chloroquine serum concentrations were determined by means of HPLC method. The pharmacokinetic parameters of Cmax, Tmax and AUC(0-6h) were determined. The extent of parasitaemia before ingestion of the drug was evaluated using appropriate stained thick and thin peripheral blood film. These data were used to evaluate the possible correlation between pharmacokinetic parameters and extent of parasitaemia. The chloroquine serum level was found to be inversely correlated with the log of degree of parasitaemia (numbers of parasites in mm3 of blood) for patients infected With p. falciparum (r2 - 0.94), however,such a correlation was not observed with/7, vivax infected patients (r2 = 0.08).https://daru.tums.ac.ir/index.php/daru/article/view/78https://daru.tums.ac.ir/index.php/daru/article/download/78/78DARU Journal of Pharmaceutical Sciences73TREATMENT AND PREVENTION OF ATRIAL TACHYARRHYTHMIAS IN CRITICALLY ILL PATIENT: THE ROLEOF MAGNESIUM SULFATE1017M. MOJTAHEDZADEHA. MOHAGHEGHIM. RASTEGARAPANAHA.M. SABZGHABA1E S. MARI20151006In this prospective, randomized study, in the general intensive care unit at Shanatee teaching hospital, we evaluated twenty patients, mean age 52+18 years and mean acute physiology and chronic health evaluation II score of 20±8, who were experiencing atrial tachyarrhythmias for more than 1 hour. After correction of their plasma potassium concentration to more than 4.0 mmof/1, patients were randomized to receive either 40 mg/kg magnesium sulfate bolus followed by 30 mg/kg/hr or 5mg/kg amiodarone bolus and 10 mg/kg/24hr infusion. Therapeutic end point was conversion to sinus rhythm over 24 hours. By logistic regression, the probability of conversion to sinus rhythm was significantly better for magnesium than for amiodarone at time 0-4 (0.6 vs.0.4), 12 (0.72 vs 0.45), and 24 (0.72vs.0.45) hours. In patients not converting to sinus rhythm, a significant decrease in ventricular response rate occurred at time zero to 0.5 hour (mean decrease 22 beats/min, P=0.0001), but there was no specific treatment effect between the magnesium and the amiodarone groups. Magnesium sulfate is superior to amiodarone in the conversion of acute atrial tachyarrhythmias, while initial slowing of ventricular response rate in non-converters appears equally efficacious with both agents.https://daru.tums.ac.ir/index.php/daru/article/view/79https://daru.tums.ac.ir/index.php/daru/article/download/79/79DARU Journal of Pharmaceutical Sciences73INVESTIGATION OF OESTROGEN AND PROGESTERONEINTERFERENCE WITH MORPHINE IDENTIFICATION IN HOURS URINE OF RATS BY TLC TECHNIQUE1822O. SABZEVARIKH. EBRAHTMI. M.R. VAEZ-MAHDAVI20151006Various screening techniques are employed by laboratories for rapid detection of morphine in urine including TLC, EIA (EMIT) and etc. There have been reports of hormonal drug-induced interference with morphine clearance from the body. The aim of this study was to evaluate the influence of oestrogen and progesterone on morphine detection in 24hr urine samples of rats by TLC. Male Wistar albino rats were housed in metabolic cages and were administered intraperitoneally oestradiol valerate or progesterone each at 10 & 20 mg/kg and morphine at 25 mg/kg once a day for 8 days. Urine samples were collected every 24 hr, rapidly checked by spot tests and assessed by TLC using lodoplatinate and/or Dragendorff reagents. Results show that neither oestradiol valerate nor progesterone interfere with morphine detection (administered before or after) in 24hr urine samples. These findings could lead to the conclusion that these drugs do not interfere with morphine detection in urine by TLC but do not exclude the possibility of interference with enzyme immunoassay techniques (EMIT). Although EMIT is a sensitive technique but its specificity can be influenced by other drugs (i.e. steroid hormones). Therefore, the interference of oestradiol and progesterone with morphine detection by EMIT remains to be further investigated. However, other factors including higher doses of oestradiol valerate, progesterone or morphine, shortening of sampling time as well as application of an alternative sample preparation technique to increase the detection sensitivity, could also be important in this regard.https://daru.tums.ac.ir/index.php/daru/article/view/80https://daru.tums.ac.ir/index.php/daru/article/download/80/80DARU Journal of Pharmaceutical Sciences73VOLATILE CONSTITUENTS OF THE FLOWER OF SALVIA HYDRANGEA DC. EX BENTH2325A. GHANNADIS.H. SAMSAM-SHARIAT F. MOATTAR20151006The essential oil obtained by steam distillation of the flowers of Salvia hydrangea DC. ex BENTH growed in Isfahan Province was investigated by TLC, GC and GC/MS. Twelve components were characterized representing 93.91% of the total components detected. Caryophyllene oxide (75.02%) and patchouli alcohol (9.59%) were the major constituents of the oil obtained in 0.25% yield.https://daru.tums.ac.ir/index.php/daru/article/view/81https://daru.tums.ac.ir/index.php/daru/article/download/81/81DARU Journal of Pharmaceutical Sciences73IN VITRO EVALUATION OF A NEW BUOYANT SYSTEM FOR ORAL APPLICATION2630F. ATYABI M. KOUCHAK20151006There are many areas in medicine and pharmacy where ion exchange resins are used. In this study ion exchange resins have been used as a floating system. The system relies on ion ex¬change resins loaded with bicarbonate, which, on contact with media containing hydrochloric acid, release carbon dioxide causing the resin beads to float. The main objective of this study was to evaluate the ability of the system to remain buoyant on the top of hydrochloric acid media and to neutralise the acid. The effect of a number of parameters such as exposure time and concentration of bicarbonate solution on the loading of resin beads was studied. Greater floating ability was observed when resin beads were treated with NaHC03 in comparison with Na2C03. Also floating times of up to 120 minutes were observed when resin beads were come in contact with HC1 (0.1M). The system has no neutralisation effect on the bulk of the medium, although pH in the raft area is higher in comparison to the acid medium bellow the raft.https://daru.tums.ac.ir/index.php/daru/article/view/82https://daru.tums.ac.ir/index.php/daru/article/download/82/82DARU Journal of Pharmaceutical Sciences73ANGOLINE AND OTHER ALKALOIDS FROM THE ROOTS OF GLAUCIUM OXYLOBUM BOISS. AND BUHSE3135A. HADJIAKHOONDIK. MORTEZA-SEMNANIH.R. INANLOOM. PIRALI-HAMEDANI A. SHAFIEE20151006Glaucium oxylobum Boiss & Buhse population Golestan forest was shown to contain four major alkaloids, protopine (0.2%), bulbocapnine (0.1%), corydine (0.3%), isocorydine (0.1%) and three minor alkaloids, dihydrochelerythrine, angoline and isocorytuberine. Glaucium oxylubum Boiss & Buhse population Roodbar was shown to contain two major alkaloids, protopine (0.39%) and dicentrinone (0.2%) and three minor alkaloids, angoline, 8-acetonyl-dihydrosanguinarine and a-allocryptopine. Angoline was detected for the first time in Glaucium.https://daru.tums.ac.ir/index.php/daru/article/view/83https://daru.tums.ac.ir/index.php/daru/article/download/83/83DARU Journal of Pharmaceutical Sciences73TENSILE STRENGTH OF CIRCULAR FLAT AND CONVEX-FACED AVICEL PH102 TABLETS3640I.HARIRIAN1 M. NEWTON20151006The mechanical properties of flat and convex-faced circular tablets made from a size fraction of microcrystalline cellulose (Avicel PH102), compacted under control conditions of pressures of 20 and 112 MPa have been assessed in term of tensile strength. The calculation of tensile strength (at), for flat-faced tablets was determined from the load (P) in diametral compression test as described by Fell & Newton ot = 2P/ (7tDt). The material tensile strength of convex-faced tablets calculated from the observed fraction loads obtained in diametral compression testing, based on the equation derived by Pitt et al at= 10P/ [TTD2 (2.84I/D - 0.126t/W+ 3.15W/D + 0.01)"1 ], where P is the fracture load, D is the tablet diameter, t is the overall tablet thickness and W is the central cylinder thickness. By comparing the tensile strength values of convex-faced tablets using porosity, tensile stress, and compaction pressure values, an optimum face-curvature in normal to unity range (D/R=0.67-1.0) and an optimum cylinder length of W/D=0.3, were found to be necessary for producing the overall strongest tablets. These optimum values varies with the formation pressure.https://daru.tums.ac.ir/index.php/daru/article/view/84https://daru.tums.ac.ir/index.php/daru/article/download/84/84