DARU Journal of Pharmaceutical Sciences72Solubility Estimation of Structurally Related Drugs in Binary Solvent Mixtures15A. JOUIBAN-GHARAMALEKIM. SABOURM.H. CHOOKHACHIZADEH-MOGHADDAMJ. HANAEE M. BARZEGAR-JALALI20151006Two empirical models for predicting solubility of structurally related drugs in binary solvent mixtures have been given. The accuracy and prediction capability of models were compared with those of a previously published model. Results indicated that the new models were superior to the previous model. Key words: Structurally related drugs, Solubility, Binary solvent mixtureshttps://daru.tums.ac.ir/index.php/daru/article/view/69https://daru.tums.ac.ir/index.php/daru/article/download/69/69DARU Journal of Pharmaceutical Sciences72Synthesis, Antifungal and Antibacterial Activity of Substituted 4,5-Dicarbomethoxy-l,3-dithioles610HALEH HAMEDIFAR ABBAS SHAFIEE20151006The title compounds are prepared from the reaction of 4,5-dicarbomethoxy-l,3-dithiolyltri-butylphosphonium tetraflou rob orate and aromatic aldehydes in the presence of triethylamine.Antifungal and antibacterial effects of the final compounds are reported.https://daru.tums.ac.ir/index.php/daru/article/view/70https://daru.tums.ac.ir/index.php/daru/article/download/70/70DARU Journal of Pharmaceutical Sciences72Stachydrine and Volatile Isothiocyanates from the Unripe Fruit of Capparis spinosa L.1113SULEIMAN AFSHARYPUOR AMIR AREFIAN JAZY20151006The alkaloid stachydrine of the unripe fruit as well as other parts of Capparis spinosa var. mucronifolia was extracted by 80% methanol, purified by column chromatography and identified by 'H NMR and IR spectroscopic methods. Volatile isothiocyanates were prepared by hydro-distillation of the autolyzed plant material and studied by GC and GC/MS methods.The volatile oil of the unriupe fruit was composed mainly of methyl isothiocyanate (39.2%), isopropyl isothio-cyanate(21.4%), and sec-butyl isothiocyanate (6.4%).https://daru.tums.ac.ir/index.php/daru/article/view/71https://daru.tums.ac.ir/index.php/daru/article/download/71/71DARU Journal of Pharmaceutical Sciences72High Performance Liquid Chromatographic Method for Determination of Dipyridamole in Human Plasma1417DAVOOD BEIGI BAND ARAB ADIMORTEZA PIRALI HAMEDANIMOHSEN AMINIÂ ABBAS SHAFIEE.20151006A simple, rapid and specific high-performance liquid chromatographic procedure is reported forquantitative determination of dipyridamole in human -plasma. The assay uses a reversed-phasehigh-performance liquid chromatographic (HPLC) and UV detection at 280nm and has a limitof detection of approximately 5ng/mL. The mobile phase consists of MeOH-H20 (60:40)adjusted to pH 3.3. Dipyridamole was extracted from plasma by back-extraction procedure, withpropranolol as the internal standard. The reproducibility of the method is satisfactoryhttps://daru.tums.ac.ir/index.php/daru/article/view/72https://daru.tums.ac.ir/index.php/daru/article/download/72/72DARU Journal of Pharmaceutical Sciences72Stereospecific Determination of Propranolol by High Performance Liquid Chromatography Using UV Detection1821EFFAT SOURIHASSAN FARSAM LEYLA AMINI20151006A method for the determination of (+)-(R)- and (-)-(S)-propranolol is described. In this assay rac-propranolol converted to diastereomeric derivatives using (+)-(S)-naphthyl-ethylisocyanate (NEIC) as chiral derivatizing reagent. Separation and quantification of the derivatives are carried out on a Silica normal-phase column using hexane-chloroform-methanol (74.5:25:0.5, v/v/v) as the mobile phase with a flow-rate of 0.8 ml/min. Reagent concentration and reaction time were examined to optimize conditions for maximum derivatization recoveries. The assay was accurate and reproducible in the concentration range of 20-320 ng/ml of (+)-(R)- and (-)-(S)-propranolol.https://daru.tums.ac.ir/index.php/daru/article/view/73https://daru.tums.ac.ir/index.php/daru/article/download/73/73DARU Journal of Pharmaceutical Sciences72Acute Effects of Peripheral Injection of Bis-2-Chloro-ethyl sulfide on the Serum Proteins Content in Rat2224DURDI QUJEQ20151006Bis-2-chloroethyl sulfide or sulfur mustard an alkylating agent after absorption through skin may enter the blood circulation and interacts with different molecules in the body. Pulmonary complication, ocular lesions, enzyme disorders and other toxic effects of sulfur mustard in the body has already been reported. Rats were injected with sub-lethal doses of Bis-2-chloroethyl sulfide intraperitoneally and at different intervals serum was collected. The effect of Bis-2-chloroethyl sulfide on the relative proportion of th^ serum proteins was investigated using electrophoresis. Our results showed that peripheral injection of Bis-2-chloroethyl sulfide had effects on the aIpha-2-globulin and gamma-globulin content.https://daru.tums.ac.ir/index.php/daru/article/view/74https://daru.tums.ac.ir/index.php/daru/article/download/74/74DARU Journal of Pharmaceutical Sciences72Use of Flumazenil to Provide Adequate Recovery Time Post-Midazolom Infusion in a General Intensive Care Unit2528MOJTABA MOJTAHEDZADEHMANSOOR RASTEGARPANAHABBAS MOHAGHEGHIALI MOHAMMAD SABZGHABAIE20151006Sedation permits patients to tolerate the various treatment modalities to which they are subjected. However it may sometimes cause prolonged sedation in critically ill patients. Flumazenil, a benzo¬diazepine antagonist, reverses midazolam-induced sedation and amnesia. We prospectively designed a double-blind randomized study to evaluate the effects of flumazenil on thirty (30) Iranian General Intensive Care Unit (ICU) patients. They were requiring mechanical ventilation for more than 12 hours and they were sedated by midazolam infusions. Sedation levels were measured hourly during the infusion, at the end of the infusion, and at 5, 15, 30, 60, and 120 min after cessation of the mida¬zolam infusion. Reversal of sedation was observed in all patients who received flumazenil, and re-sedation occurred in seven of these patients. Reversal was not seen in any of the patients who receiv-ed placebo.https://daru.tums.ac.ir/index.php/daru/article/view/75https://daru.tums.ac.ir/index.php/daru/article/download/75/75DARU Journal of Pharmaceutical Sciences72Disposition of Alpha-1-Antitrypsin in the Isolate Perfused Rabbit Lung2933MOHAMMAD K. HASSANZADEH PHILIP R. MAYER20151006The potential for delivering large molecular weight proteins into the lungs to reach local or systemic sites of action was investigated by examining the disposition of alpha-1-antitrypsin in the isolated rabbit lung. Alpha-1-antitrypsin, a model protein, was measured in the periusion medium following intravascular administration and was found to remain constant, indicating limited uptake or metabolism by lung tissue. Intrabronchial instillation of 10 mg of alpha-1-antitrypsin in water resulted in no measurable concentration in the recirculating perfusate during the two hours experiment. These data suggest that transport of large proteins may be limited across lung-blood membrane barriers in either direction. Though this would limit the ability of inhaled drugs with large molecular weights to reach the general circulation, proteins which are used to treat respiratory diseases, such as alpha-1-antitrypsin, might be delivered locally by inhalation with only negligible systemic exposure.https://daru.tums.ac.ir/index.php/daru/article/view/76https://daru.tums.ac.ir/index.php/daru/article/download/76/76