DARU Journal of Pharmaceutical Sciences61-2Swelling characteristics of hydroxyethylmethacrylate/ methacrylic acid pH -sensitive hydrogel as a drug delivery system110M. Falamarzian- J. Varshosaz20151006Hydroxyethyl methacrylate /methacrylic acid (HEMA/MAA) copolymer cross-linked with ethylenglycol dimethacrylate was prepared by a bulk.free radical polymerization method. The results indicate that this polymer is a pH -sensitive hydrogel which is collapsed in the acidic medium but completely swollen in the alkaline and neutral pH . it was determined that a proportion of 40% of MAA, the ionizing monomer of this hydrogel, was the best concentration among the different percentages used which showed a non-Fickian water transport mechanism. Increasing MAA content from 20 to 70% was accompanied with a change in water transport mechanism from Fickian to non-Fickian. However, increasing the percentage of MAA from 40 to 70 didn't improve the swelling capacity of this polymer. Pore size determination by a solute exclusion technique, showed the greatest distribution in the hydrogel with 40% MAA compared to other percentages of this monomer used. About 75% of the pores were less than 16.5 A in diameter in this polymer which is important specially in loading the hydrogel with macromoiecular drugs like proteines.https://daru.tums.ac.ir/index.php/daru/article/view/56https://daru.tums.ac.ir/index.php/daru/article/download/56/56

DARU Journal of Pharmaceutical Sciences61-2The distribution of inole alkaloids in different organs of Catharanthus roseus G. Don. (Vinca rosea L)1124Hassan EbrahimzadehAzra Ataei -Azimi4 Mohammad-Reza Noori-Dafoi20151006The study of alkaloid extract of the leaf of Vinca rosea by TLC showed the existence of 13 bands, 7 bands of them were: Serpentine, Vincristine, Vinblastine, Ajmaline, Catharantine, Vindoline and Ajmalicine. The existence of these 7 alkaloids was confirmed in the young leaves, old leaves and the roots of the plant by HPLC. Furthermore, two alkaloids with the short retention times and one alkaloid with the medium retention time in the young leaf, three alkaloids with the short retention time and one alkaloid with long retention time in the old leaf, and one alkaioid with the short retention time and two other alkaloids with the long retention times in the root, were observed.The study of absorption spectrum of alkaloid extract and its comparison with absorption spectrum of ajmalicine showed that the latter can be used for drawing a standard curve and detecting the amount of total alkaloids. The total alkaloids in fresh root, old leaf and young leaf were 2.1 mg , 1.3 mg and 0.9 mg/g respectively, Vindoline and Catharantine were major alkaloids in all of them. However, their amount were more in the root (1.2 mg/ g of fresh material, 0.85 in the old leaf and 0.38 in the young leaf). Vinblastine existed in all three samples but its amount was more in the root {0.22 mg per gramme of the fresh material in the root, 0.26 in the young leaf and 0.003 in the old leaf).Ajmalicine was detected only in the leaf and its amount was more in young leaf than the old leaf (0.141 mg/g of the fresh material in the young leaf and 0.013 in the old leaf). Serpentine was seen in all of the studied organs but its amount was more in the young leaf than other organs (0.192 mg/ g of the fresh material in the young leaf, 0.11 in the root and 0.07 in the old leaf). Ajmaline existed in all of the organs in minute amount but in the old leaf was more (0 .07 mg/g of the fresh material in the old !eaf,0.044 in the young leaf and 0.04 in the root) . The percentage of unknown alkaloids were low, except in the root (20.5% of total alkaloid).https://daru.tums.ac.ir/index.php/daru/article/view/57https://daru.tums.ac.ir/index.php/daru/article/download/57/57

DARU Journal of Pharmaceutical Sciences61-2Morphological and Phytochemical Investigations on Crataegus curvisepala and Crataegus oxyacantha2536N. Ghassemi DehkordiA.R. GhannadiF.Mohtaj20151006Several species of the genus Crataegus have been used for treatment of hypertension and certain cardiac disorders. Over than 20 species of this plant is extensively grew in Iran. One of these species is C. curvisepala.in this study, C.curvisepala was examined botanically and phytochemically in comparison to C, oxyacantha.Morphological as well as microscopical characteristics of C. curvisepala was examined and some differences distinguished from C. oxyacantha. By means of TLC in comparison to authentic samples,rutin, hyperoside and chlorogenic acid were identified in these plants. By preparative TLC method, rutin is isolated and then purified from these plants. The structure of rutin was determined by the UV-Vis. Techniques in methanol and by addition of the shift reagents and hydrolysis. The quantitative determinations of flavonoids in these plants were also performed by using an UV-Vis. spectroscopy method.https://daru.tums.ac.ir/index.php/daru/article/view/58https://daru.tums.ac.ir/index.php/daru/article/download/58/58

DARU Journal of Pharmaceutical Sciences61-2A novel model for prediction solubility in binary solvent system3747M.Barzegar-jalaiA. Jouyban-GharamalekiJ. Hanaee M.H. Chookhachizadeh-Moghaddam20151006A new seven parameter model for calculating and predicting solid solubility in binary solvent systemshas been presented as follows :logxm=A0+A1/fA+A3(fA-FB)2+A4(FA+FB)3+A5(81-82/81)3+A5(V1-V2/V1)3Where Xm is mole fraction solubility of solid, Ao-As denote the parameters or coefficients of the model, IA and fB are volume fractions of the solvents A and B in the absence of the solute in the mix'Iure,b1 and b2 represent the solubility parameters of the solvent mixture and solute, V1 and V2 are molar volumes of the solvent mixture and solute, respectively. I'A and I'B are given by I'A=0.96 fA+0.02 and I'B=0.96 Is+0.02 , V1 is calculated by means 01 V1=fA.VA+fBVS in which VA and Vs are molar volulmes of the neat solvents A and B. Also, ()1 is determined from : ()1 =fA,{)A+fB,{)B where OA and as represent the solubility parameters of the pure solvents. All the values of () and V can readily be calculated from the published group contribution tables available in literature. The coefficients of Ao-As can be easily estimated by means of a multiple regression analysis using an ordinary personal computer. The accuracy and prediction capability of the model were compared with those of six previous models i.e., log-linear, extended Hildebrand, polynomial statistical response mixture, nearlly ideal binary solvent (NIBS) , modified Wilson and double log-log, using data of 35 systems published in models in most cases. literature. The proposed model was superior to the mentionedhttps://daru.tums.ac.ir/index.php/daru/article/view/59https://daru.tums.ac.ir/index.php/daru/article/download/59/59

DARU Journal of Pharmaceutical Sciences61-2Adhesion of Pharmaceutical Binding Agents I-Adhesion to polymeric materials4853Hossain OrafaiMicheal S.Spring20151006Adhesion of three commonly used pharmaceutical binding agents, HPMC , PVP and Gelatin to five different polymeric sheet materials was studied. After conditioning, the bond strength of the specimens were measured by shear testing method using a suitablely designed apparatus. The results were correlated to the surface energies and the solubiiity parameters of the adherends. It is concluded that the thermodynamic properties and the solubility parameters are dominant when the mechanisms of adhesion are by adsorption and diffusion respectively.https://daru.tums.ac.ir/index.php/daru/article/view/60https://daru.tums.ac.ir/index.php/daru/article/download/60/60

DARU Journal of Pharmaceutical Sciences61-2Composition and Antimicrobial Activity of Essential Oil of Ziziphora teniur, Population Iran5660Katayoun Javidnia Mojtaba TabatabaieeAbbas shafiee20151006The volatile constituents of Ziziphora teniur (Labiatae) from three different regions of Iran, were studied by GLC and GC-MS. The major component was Pulegone.The composition of the essential oil from three different regions were compared and antimicrobial activity of the essentia! oil was studied.https://daru.tums.ac.ir/index.php/daru/article/view/61https://daru.tums.ac.ir/index.php/daru/article/download/61/61