DARU Journal of Pharmaceutical Sciences152In-vitro percutaneous absorption of losartan potassium in human skin and prediction of human skin permeability5360Petkar K.C.Kuchekar S.B20151006This study describes the feasibility of transdermal controlled administration of Losartan potassium (LP) across human cadaver skin. Study also defines the influence of capsaicin, sex and site of application on permeation characteristics and determined an appropriate animal model for human skin permeability. The permeation of LP of various formulations was studied using Keshary-Chein diffusion cell. Optimized controlled formulation (without capsaicin) released 42.17% (±1.85) of LP in 12 hr whereas treatment formulation (with capsaicin 0.028 % w/v) released 48.94% (±1.71) of LP with significant difference on null hypothesis. Influence of sex showed statistically significant difference for permeation of LP through male and female rats, as well as male and female mice across both the abdominal and dorsal sides of the skin (phttps://daru.tums.ac.ir/index.php/daru/article/view/305https://daru.tums.ac.ir/index.php/daru/article/download/305/305