DARU Journal of Pharmaceutical Sciences22-32D 1H -13C Heteronuclear Shift Correlation Of 2a - Hydroxy Aiantolactone From Pulicaria Undulata C.A. Mey250259A. RustaiyanZ. Habibi20151006We have reported recently the isolation and characterization of several sesquiterpene lactones from Pulicaria undulata (1).The lactones were isolated from an Et20 - Petrol (1:3) fraction by different chromatographic techniques including HPLC (RP 8, MeOH - H2O, 13:7).In this way three eudesmanolides 1 - 3, a guaianolide 4, a nor -guaianolide 5, as well as the pseudoguaianolide 6 and the xanthanolide 7 were isolated. One of the eudesmanolides (2a - hydroxy aiantolactone), 1, was present as the main component.Such lactones being known as biologically active substances, we have decided to describe for the first time a detailed interpretation of proton, 1H -NMR, 13C - NMR and 2D lH -13C - heteronuclear shift correlation spectra of 2a - hydroxy aiantolactone. The stereochemistry of C - 2 , C - 7 and C - 8 was determined by the NOESY experiments, H - 7 and H - 8 are in the a configuration and H - 2 is in the b configuration.https://daru.tums.ac.ir/index.php/daru/article/view/30https://daru.tums.ac.ir/index.php/daru/article/download/30/30