DARU Journal of Pharmaceutical Sciences113A Stereological Study of Diabetic Kidney Following Administration of Different Doses of Streptozotocin.115119Zahra HeidariHamid-Reza Mahmoudzadeh SaghebHooshang RafighdoostAbbas-Ali MoeinMohammad-Hosein Noori MugahiBagher Minaii20151006The absolute glomerular volume and total glomerular number as well as renal volume in diabetic rats following administration of different doses of Stereptozotocin (STZ) have been estimated by using unbiased stereological methods. 30 male Wistar rats were randomly divided into 5 groups. Diabetes were induced by IP injection of 15mg/kg, 45mg/kg and 90 mg/kg of STZ. Fifty six days after IP injection, animals were anesthetized by ketamine hydrochloride, the kidneys were excised and fixed in modified Lilli´s solution. After tissue processing and staining, stereological methods used to estimate volume of different zones of kidney, absolute glomerular volume and total glomerular number. This investigation revealed that increment of cortical tissue volume in all groups and increase in medullary volume only in the group 90 mg/kg of STZ (phttps://daru.tums.ac.ir/index.php/daru/article/view/180https://daru.tums.ac.ir/index.php/daru/article/download/180/180