DARU Journal of Pharmaceutical Sciences111Comparartive Study of Zataria Multiflora and Anthemis Nobelis Extracts With Myrthus Communis Preparation in The Treatment of Recurrent Aphthous Stomatitis237Shahin JafariMassoud AmanlouKatayoun Borhan-mojabiHassan Farsam20151006Recurrent aphthous stomatitis (RAS) is a prevalent and complicated disorder and its management is directed toward treatment of symptoms. The purpose of this study was to compare the efficacy of three herbal preparations in the management of RAS. One hundred and one out of 115 patients with minor aphthae were selected and randomly divided into four groups. Groups A, B and C received topical preparations of Zataria multiflora, Anthemis nobilis and a 50 % (v/v) mixture of Zataria multiflora and Anthemis nobilis respectively. Groups D (positive control) received Myrthus communis (Myrtle, mouth rinse), which reported to be efficient in the management of RAS. The time of pain elimination and the duration of the thorough healing were recorded. Mean time of pain elimination showed significant differences (phttps://daru.tums.ac.ir/index.php/daru/article/view/163https://daru.tums.ac.ir/index.php/daru/article/download/163/163