DARU Journal of Pharmaceutical Sciences12A New Sensitive Procedure for the Determination of Codeine in Pharmaceuti Preparations95101FAZEL SHAMSAFUROOZANDEH HAKKI20151006A spectrophotometry procedure for the determination of codeine based on the reaction with bromthymol blue was developed. A yellow complex forms and is easily extractrable by chloroform at PH 5.6. The mole ratio of bromthymol blue in the complex is 1:1. The absorbance of the complex obeys Beer's law over the concentratic range of 2-14 ug of codeine per ml of chloroform. This procedure can be carried out in the presence of many common excipients without interference. In the presence of morphine to the extent of 60% of codeine present the analysis of codeine could be carried out without interference.https://daru.tums.ac.ir/index.php/daru/article/view/14https://daru.tums.ac.ir/index.php/daru/article/download/14/14